IRVING H . ZUCKER and JOSEPH P . GILMORE Dog Evidence for an Indirect Sympathetic Control of Atrial Stretch Receptor Discharge
نویسندگان
چکیده
Experiments were performed to determine the influence of cardiac sympathetic efferent nerve stimulation on the discharge rate of atrial type B stretch receptors in the anesthetized, open-chest dog. In all experiments, the left stellate ganglion was stimulated following volume expansion. To determine the effects of stellate stimulation, the responses of atrial receptors were observed during the withdrawal of blood in steps following intravascular volume expansion. Stimulation of the stellate ganglion decreased receptor discharge and left atrial pressure in all experiments. A change from a control left atrial pressure of 2.5 cm H2O (in peak left atrial u-wave pressure) resulted in a mean increase in receptor discharge of 6.6 ±1 .4 spikes/cardiac cycle during stellate stimulation; however, a change from a control pressure of 0.0 cm H2O resulted in a mean decrease in receptor discharge of 1.5 ± 1.5 spikes/cardiac cycle. The curves relating the change in atrial receptor discharge to the change in left atrial pressure during hemorrhage and the curve for these parameters during stellate stimulation were not significantly different from each other. Apparently, the decreased discharge during sympathetic stimulation was the result of a decline in left atrial pressure rather than a result of any direct effect on the receptor per se.
منابع مشابه
IRVING H . ZUCKER and JOSEPH P . GILMORE
Experiments were performed to determine the influence of cardiac sympathetic efferent nerve stimulation on the discharge rate of atrial type B stretch receptors in the anesthetized, open-chest dog. In all experiments, the left stellate ganglion was stimulated following volume expansion. To determine the effects of stellate stimulation, the responses of atrial receptors were observed during the ...
متن کاملEvidence for an indirect sympathetic control of atrial stretch receptor discharge in the dog.
Experiments were performed to determine the influence of cardiac sympathetic efferent nerve stimulation on the discharge rate of atrial type B stretch receptors in the anesthetized, open-chest dog. In all experiments, the left stellate ganglion was stimulated following volume expansion. To determine the effects of stellate stimulation, the responses of atrial receptors were observed during the ...
متن کاملLeft Atria I Receptor Discharge during Atrial Arrhythmias in the Dog
Afferent receptor discharge originating in the atria was recorded from slips of the cervical vagus in the open-chest dog. The activity of two types of atrial receptor endings was identified. Type A receptors exhibited a discharge pattern that was synchronous with the a wave of the atrial pressure pulse in the control recordings, and type B receptors discharged only during the v wave of the atri...
متن کاملThe response of atrial stretch receptors to increases in heart rate in dogs.
The discharge characteristics of type B left atrial receptors were analyzed during alterations in heart rate. Recordings were made from single-fiber preparations of the left cervical vagus of pentobarbital-anesthetized, open-chest dogs. The heart was paced following a sinoatrial crush at frequencies ranging from 60 to 240 beats/min. Left atrial transmural pressure was varied at each heart rate ...
متن کاملThe mechanism of adaptation of left atrial stretch receptors in dogs with chronic congestive heart failure.
Chronic congestive heart failure (CHF) was induced in dogs by the construction of an aorto-caval fistula below the level of the renal arteries. Aorto-caval fistula dogs showed signs of CHF which included ascites, hind limb edema, and pulmonary congestion. Ventricular catheterization indicated a significantly higher left ventricular end diastolic pressure and lower maximum velocity of left ventr...
متن کامل